Innate Immune Pathway Links Obesity to Insulin Resistance
Comments:insulin resistance leads to excess FFA, obesity and activation of the innate immune signaling. This uses TLR4 and stimulates NF-KappaB transcription. The result is inflammation and...
View ArticleHypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance...
Comments:chronic overnutrition (ie overeating) results in activation of the IKKBeta/NF-kappaB complex, increase NF-kappaB transcription and inflammation. This leads to ER (endoplasmic reticulum)...
View ArticleLimited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient...
Comments:curcumin shown to inhibit NF-kappaB through a IL-10 dependent pathway. IL-10 is required and curcumin appears to augment the inhibition of NF-kappaB - Nathan GoodyearTags:curcumin, IL-10,...
View ArticleNaturally occurring NF-kappaB inhibitors. [Mini Rev Med Chem. 2006] - PubMed...
Comments:natural inhibition of NF-KappaB - Nathan GoodyearTags:NF-KappaB, inflammation, overweight, obesity, natural inhibitionby:Nathan Goodyear
View ArticlePreadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin...
Comments:proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade. This plays a key role in the obesity epidemic. - Nathan GoodyearTags:LPS, lipopolysaccharides,...
View ArticleShort-term feeding of baicalin inhibits age-... [Mech Ageing Dev. 2006] -...
Comments:Baicalin, component of skullcap, shown to inhibit NF-kappaB activation - Nathan GoodyearTags:skullcap, baicalin, NF-KappaB, inflammation, oxidative, stress, aging, Cox-2, iNOSby:Nathan Goodyear
View ArticleCordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition...
Comments:cordyceps shown to decrease LPS stimulated macrophage inflammation. Specifically, IL-1Beta, IL-6, TNF-alpha were shown to be inhibited. Also, NF-kappaB inhibition was found with cordyceps -...
View ArticleCurcumin works synergistically with paclitaxel to inhibit breast cancer in a...
Comments:curcumin shown to augment paclitaxel in breast cancer treatment. Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased...
View ArticleCurcumin attenuates the development of allergic airway inflammation and...
Comments:curcumin shown to inhibit allergic airway inflammation, through NF-kappaB inhibition. This has implications in asthma flares. - Nathan GoodyearTags:curcumin, inflammtion, airway, allergy,...
View ArticleThe Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed...
Comments:Curcumin downregulates HER-2 oncoprotein in breast cancer in vitro and in vivo. IN this study, the combination of taxol and curcumin was comparable to that of taxol and perceptin. - Nathan...
View ArticleNF-κB and cancer: how intimate is this relationship
Comments:NF-KappaB plays a critical role in the development of cancer. NF-kappaB is a transcription factor that promotes inflammation. This reveals the important relationship between inflammation and...
View ArticleThe Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice...
Comments:NF-kappaB and the associated inflammatory pathways are associated with tumor growth, vascular growth within the tumor, and increased migration of macrophages--thus more inflammation. When...
View ArticleMolecular inflammation: Underpinnings of aging and age-related diseases...
Comments:chronic inflammation appears to be the major player in aging and age-related chronic diseases - Nathan GoodyearTags:inflammation, NF-KappaB, aging, disease, ageingby:Nathan Goodyear
View ArticleSleep Loss Activates Cellular Inflammatory Signaling
Comments:lack of sleep increases inflammation. This study showed how one night of sleep disruption can stimulate NF-KappaB activation and thus inflammation. - Nathan GoodyearTags:insomnia, sleep,...
View ArticleDehydroepiandrosterone-Sulfate Inhibits Nuclear Factor-κB-Dependent...
Comments:DHEA inhibits NF-kappaB, thus inhibiting inflammation. - Nathan GoodyearTags:DHEA, DHEA-S, inflammation, NF-KappaB, antioxidantby:Nathan Goodyear
View ArticleDehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus...
Comments:Fascinating article: DHEA found to decrease NF-KappaB activity in the hippocampus region of the brain. This has implications in protecting the brain. In this study, the implication was...
View ArticleTHE NEUROPROTECTIVE PROPERTIES OF CALORIE RESTRICTION, THE KETOGENIC DIET,...
Comments:Fantastic read on the biochemical benefits of calorie restriction and a ketogenic diet. - Nathan GoodyearTags:calorie restriction, ketogenic diet, NF-KappaB, BDNF, neuroprotection, SIRT1,...
View ArticleLow Doses of Lipopolysaccharide and Minimally Oxidized Low-Density...
Comments:LPS and minimal oxidized LDL have synergistic effects on inflammatory signaling. Together the two promote inflammatory signaling from macrophages at much lower levels than either one alone....
View ArticleCrossroads of Estrogen Receptor and NF-{kappa}B Signaling -- Biswas et al....
Comments:This study looked at estrogen receptors and breast cancer. But, they found anti estrogen therapy might actually increase NF-KappB activity i.e.inflammation. In contrast, ER inhibited...
View ArticleC-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin...
Comments:The summary statement of this article says it all: "chronic inflammatory state may induce insulin resistance and endothelial dysfunction..." Inflammation causes insulin dysfunction. And in...
View Article
More Pages to Explore .....